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A pharmacotherapy specialist is the anticoagulation clinic manager at a for-profit institution.
One of the internal medicine physicians in this institution is interested in submitting a research grant application to the National Institutes of Health (NIH) to study the effectiveness of low- intensity warfarin therapy on prevention of recurrent venous thromboembolism in patients.
This was the subject of the PREVENT trial.
With regard to the grant application, the pharmacotherapy specialist should inform the physician about which of the following restrictions?

• A. The NIH provides grants only to nonprofit organizations.
• B. NIH-funded research can take place only on the campus.
• C. The NIH funds only novel research.
• D. The NIH funds only studies involving drugs that have not yet been FDA-approved.

A patient presents with palpitations and shortness of breath. A 12-lead ECG reveals a regular narrow QRS complex supraventricular tachycardia. What is the recommended first-line therapy?

• A. Lidocaine
• B. Verapamil
• C. Amiodarone
• D. Adenosine

Which of the following components of a grant proposal defines the study hypothesis?

• A. Background
• B. Specific aims
• C. Research design
• D. Significance

From ethical and scientific validity standpoints, in addition to double blinding, which of the following research designs is best for determining a new medication's relative efficacy in treating acute stroke?

• A. Parallel design comparing the new therapy with the best standard therapy
• B. Placebo-controlled, randomized, parallel design
• C. Placebo-controlled, crossover design
• D. Crossover design comparing the new therapy with the best standard therapy

An obtunded 61-year-old Woman weighing 45 kg with Worsening renal function is admitted to the hospital. She has a recent history of several days of nausea, fatigue, pruritus, and a metallic taste in her mouth. Her medical history includes diabetes, heart failure, and COPD. Admission laboratory values include:
SERUM CHEMISTRY
Sodium: 135 mEq/L
Potassium: 5.7 mEq/L
Chloride: 100 mEq/L
HCO3: 15 mEq/L
BUN: 96 mg/dL
Creatinine: 5.5 mg/dL
Glucose: 300 mg/dL
Calcium: 7.4 mg/dL
Serum ketones: Negative
ABGS (Room Air)
pH: 72
PaCO2: 30 mm Hg
PaO2: 75 mm Hg
O2 Sat: 90%
Chest X-ray shows a flattened diaphragm. Current medications include furosemide, fluticasone salmeterol, and glipizide. Which acid-base disorder does this patient exhibit?

• A. Metabolic acidosis secondary to end-stage renal disease
• B. Respiratory acidosis secondary to COPD
• C. Metabolic acidosis secondary to diabetic ketoacidosis
• D. Metabolic acidosis secondary to furosemide use